Neurescence Quartet® is a light-weight fluorescence microscope and data collection software package optimized for functional imaging of neuronal circuits and calcium imaging. Simultaneous calcium imaging can be performed in up to four brain and spinal cord regions in freely behaving rodents. Quartet® features four lightweight and flexible optical fibre bundles that weigh in total <1.5 g, with a connector design that allows for simple focus adjustment, and focus lock mechanism. As a trusted partner in your laboratory, we look forward to finding the right solution to support your neuroscience research.